Name: N-chlorosuccinimide

English name: N-Chlorosuccinimide

Other name: N-chlorosuccinimide N-chlorosuccinimide succinyl chloride imine succinyl chloride imide

Chemical formula: C4H4ClNO2

Molecular weight: 133.53

Melting point: 144-150℃

Closeness 1.5g/cm3

EINECS:204-878-8

Melting point: 144-150℃

Relative density: 1.5g/cm3

use

1. An important chlorinating agent that can chlorinate aromatic aldehydes without affecting the aromatic ring. In the chlorination of aniline and N-alkylaniline (mainly ortho), the chlorination of a-aminopyridine, the dehydrochlorination and degradation chlorination of a-phenylthioamide, and the monochlorination of cyclopentadiene Both have higher yields than chlorine, tert-butyl hypochlorite, and chloramine T. As oxidants, diols can be oxidized to lactones, primary (secondary) alcohols are oxidized to aldehydes (ketones), and B-hydroxyketones are oxidized to B-diketones. It can selectively break the peptide bond formed by tryptophan under acidic conditions. It can also be used in the synthesis of allylamine, B, R-unsaturated amino acids and their derivatives.

2. Pharmaceutical intermediates. Commonly used in the synthesis of antibiotics, such as benzyl cephalosporin, can also be used to prepare rubber additives.

3. N-chlorosuccinimide (NCS) is a convenient electrophilic addition and electrophilic substitution reagent, commonly used in the chlorination of sulfides, sulfones and ketones, and can also be used to synthesize N-chlorine amines .