Name: Olmesartan

CAS : 144689-24-7

Molecular formula: C24H26N6O3

Molecular weight: 446.50200

Compound introduction

Basic properties

Chinese name: Olmesartan

Chinese alias: Olmesartan medoxoic acid; 4- (1-hydroxy-1-methylethyl) -2-propyl-1- [2 '-(tetrazol-5-yl) phenyl] phenyl] methyl Imidazole-5-carboxylic acid;

English name: olmesartan

English alias: 5- (2-hydroxypropan-2-yl) -2-propyl-3-[[4- [2- (2H-tetrazol-5-yl) phenyl] phenyl] methyl] imidazole-4-carboxylic acid; Olmesartan Acid;

Exact mass: 446.20700

Physical and chemical properties

Appearance and properties: white solid

Density: 1.33

Melting point: 186-188ºC

Boiling point: 738.3ºC at 760mmHg

Flash point: 400.3ºC

Refractive index: 1.671

Vapor pressure: 6.89EmmHg at 25 ° C

Indication: For hypertension.

Contraindications:1. People who are allergic to olmesartan.

2. Pregnant women.

Drug interaction

1. Combination with licorice can reduce the effect of AngⅡ receptor antagonists. The possible mechanism is that licorice can cause high mineralocorticoid effect.

2. Combination with ephedra can reduce the effect of AngⅡ receptor antagonists. The possible mechanism is that the sympathomimetic activity of ephedrine and pseudoephedrine in ephedra can produce antagonistic effects.

3. Combination with yohimbine can reduce the effect of Ang II receptor antagonists. The possible mechanism is that yohimbine can increase the release of norepinephrine.

4. In combination with antacids, the bioavailability of olmesartan has not changed significantly.